In case you missed, the latest steam beta embeds a modified version of wine that promises to run windows games without any additional configuration.
Games that use directx 11 and 12 will run on vulkan and vr games will be supported as well.
native game works better. In my old lenovo 2009 year Skyrim in wine with 30-40 fps, in windows 60. Skyrim in wine and Skyrim in windows works! But I prefer windows)
PS: my girlfriend adores Skyrim and Enderal . (who doesn’t know about Enderal - LOOK IT! )